Reversibility of Atherosclerosis in Cholesterol-Fed Rabbits
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چکیده
منابع مشابه
Reversibility of atherosclerosis in cholesterol-fed rabbits.
Previous studies have attempted to demonstrate the reversibility of rabbit atherosclerosis after discontinuance of cholesterol feeding or by other measures. These attempts have been largely unsuccessful. In all the studies, atherosclerosis was induced by cholesterol feeding for several months. At the end of these prolonged periods, the animals had advanced aortic lesions. The present study soug...
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The effects of diltiazem, a calcium antagonist, on the development of atherosclerosis were studied in Japanese white rabbits. The rabbits were examined at the end of 10 weeks on the following regimens; a diet of standard pellets and daily intraperitoneal (ip) injections of saline; a diet of pellets containing 1% cholesterol and daily ip injections of saline; or a diet of pellets containing 1% c...
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Urotensin II (UII) is a vasoactive peptide composed of 11 amino acids that has been implicated to contribute to the development of cardiovascular disease. The purpose of this study was to investigate whether UII affects the development of atherosclerosis in cholesterol-fed rabbits. UII was infused for 16 weeks through an osmotic mini-pump into male Japanese White rabbits fed on a high-cholester...
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Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17p-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabbits each and received oral treatment with norethisterone acetate, levonorgestrel, ...
متن کاملOxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits.
Oxidized lipoproteins may play a role in atherosclerosis. Recently, we have demonstrated that the levels of oxidized fatty acids in the circulation correlate directly with the quantity of oxidized fatty acids in the diet and that dietary oxidized fatty acids accelerate atherosclerosis in rabbits. The present study tests the hypothesis that oxidized cholesterol in the diet accelerates the develo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1968
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.22.2.135